A brilliant and respected criminal psychologist, Dr. Miranda Grey (Halle Berry) is an expert at knowing what is rational. What is logical. What is sane. But Miranda's comfortable and stable life are thrust into terrifying jeopardy after a cryptic encounter with a mysterious young girl leads to a nightmare beyond her wildest imagination. Miranda suddenly finds herself confined to the very institute she worked in along side the highly unstable patients she used to treat like Chloe (Penelope Cruz). Accused of a brutal and savage murder and clinging to her sanity, Miranda is forced to rely on her instincts rather than the facts. As Chloe draws her deeper into her own personal hell and Dr Pete Graham (Robert Downey Jr) struggles with their doctor-patient-relationship, Miranda must determine if she is being driven to madness... or closer to the truth.